Cardiac transgenic matrix metalloproteinase-2 expression directly induces impaired contractility
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چکیده
منابع مشابه
Cardiac transgenic matrix metalloproteinase-2 expression directly induces impaired contractility.
OBJECTIVE Matrix metalloproteinase-2 (MMP-2) plays a major role in dysfunctional ventricular remodeling following myocardial injury induced by ischemia/reperfusion and heart failure. To directly assess the role of MMP-2 in the absence of superimposed injury, we generated cardiac-specific, constitutively active MMP-2 transgenic mice. METHODS Morphologic and functional studies were carried out ...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2006
ISSN: 0008-6363
DOI: 10.1016/j.cardiores.2005.08.023